iREJU and Tranexamic Acid vial /set dark circle treatment (2 treatments)

Description

Tranexamic Acid and PN: Modern Innovations in Aesthetic Dermatology

In recent years, aesthetic dermatology has embraced advanced treatments to address common skin concerns, such as dark circles under the eyes and age-related changes like collagen loss. Among these, tranexamic acid (TXA) and polynucleotides (PN) have gained popularity for their effectiveness and safety.

Tranexamic Acid for Dark Circles

Dark circles around the eyes can result from various factors, including pigmentation, vascular issues, and thinning skin. Tranexamic acid, traditionally used to manage bleeding disorders, has emerged as a targeted treatment for pigmentation-related dark circles.

How Does TXA Work?

Tranexamic acid works by inhibiting plasmin, an enzyme that plays a role in inflammation and melanin production. By reducing melanogenesis (the production of skin pigment), TXA helps lighten hyperpigmented areas, including those around the eyes.

Application in Aesthetics:

1.Topical Treatments:

TXA is often included in eye creams or serums, delivering localized benefits. Consistent application can help reduce the appearance of dark circles over time.

2.Injectable TXA:

Microneedling or mesotherapy with TXA delivers the substance deeper into the skin, providing faster and more noticeable results by directly targeting pigmentation pathways.

3.Synergy with Other Treatments:

TXA is frequently combined with other therapies, such as lasers or chemical peels, to enhance its depigmentation effects.

Polynucleotides (PN) as a Skin Booster

Polynucleotides (PN) are derived from DNA fragments that stimulate skin repair and rejuvenation. They have become a popular choice for improving skin texture, elasticity, and hydration, particularly in areas prone to collagen loss.

How Do PN Work?

Polynucleotides promote fibroblast activity, the cells responsible for producing collagen and elastin. By enhancing cellular repair and increasing collagen synthesis, PN restore skin density, improve elasticity, and provide a more youthful appearance.

Application in Aesthetics:

1.Skin Booster Injections:

PN are delivered via mesotherapy or microneedling, targeting the dermis. This stimulates collagen production, improves skin hydration, and creates a smoother texture.

2.Collagen Stimulation:

PN treatments are ideal for addressing fine lines, sagging skin, and dullness by restoring the skin’s structural integrity.

3.Combination with Other Therapies:

PN can be used alongside hyaluronic acid fillers, PRP (Platelet-Rich Plasma), or energy-based devices (such as lasers and radiofrequency) for comprehensive skin rejuvenation.

Benefits and Safety

Both TXA and PN treatments are considered safe when performed by trained professionals. They are minimally invasive, with little to no downtime, making them attractive options for patients seeking effective solutions with minimal disruption to daily life.

Conclusion

Tranexamic acid and polynucleotides represent cutting-edge advancements in aesthetic medicine. TXA offers targeted treatment for pigmentation-related dark circles, while PN boosts collagen and improves overall skin health. By addressing specific concerns with scientifically-backed therapies, these treatments can help patients achieve brighter, healthier, and more youthful skin.

For best results, consult with a qualified dermatologist or aesthetic practitioner to determine the most suitable treatment plan for your individual needs.

Protocol for Mixing and Administering Tranexamic Acid with PN (I-Reju)

This protocol provides detailed instructions for preparing and administering a mixture of tranexamic acid and I-Reu polynucleotides for under-eye rejuvenation treatments. Follow these steps to ensure safety, efficacy, and optimal results.

Materials Needed:
1.      1 vial of tranexamic acid (concentration as specified by the product)
2.      1 syringe of I-Reju polynucleotides
3.      Syringe mixer (Luer-lock connector)
4.      Sterile 27G or 25G cannula
5.      Alcohol swabs
6.      Sterile gloves
7.      Sharps disposal container

Preparation Steps:

Step 1: Aseptic Setup
1.      Wash your hands thoroughly and wear sterile gloves.
2.      Disinfect the vial of tranexamic acid and the I-Reu syringe with an alcohol swab.
3.      Prepare a sterile work area to minimize contamination.

Step 2: Drawing Tranexamic Acid
1.      Attach a sterile needle to a 1 mL syringe.
2.      Withdraw the required amount of tranexamic acid from the vial (5 mL or as recommended by the product’s guidelines).
3.      Remove the needle and set the syringe aside.

Step 3: Mixing Products
1.      Remove the protective cap from the I-Reu syringe.
2.      Attach the syringe containing tranexamic acid to the I-Reju syringe using a syringe mixer.
3.      Gently push the contents of the syringes back and forth through the mixer 5–6 times to ensure a homogenous mixture.
4.      Once mixed, withdraw the combined solution into one syringe.

Step 4: Dividing the Mixture
1.      Detach the syringe mixer.
2.      Divide the mixture into two equal parts (typically 0.75–1 mL each, depending on the total mixture volume).
3.      Place one syringe in a sterile container for the second procedure (store according to product stability guidelines).

Injection Procedure:

Step 1: Prepare the Patient
1.      Disinfect the under-eye area with an alcohol swab.
2.      Use topical anesthetic if necessary (optional).

Step 2: Cannula Insertion
1.      Use a 27G or 25G cannula to minimize bruising and ensure precise delivery.
2.      Create an entry point with a fine needle near the tear trough region.
3.      Insert the cannula through the entry point, advancing carefully along the sub-dermal plane under the eye.

Step 3: Inject the Mixture
1.      Slowly inject the mixture into the sub-dermal layer of the tear trough region using retrograde threading or fanning techniques.
2.      Distribute the product evenly to avoid overfilling.

Post-Procedure Instructions:
1.      Advise the patient to avoid vigorous rubbing, makeup, or heat exposure (e.g., sauna, sun) for 24–48 hours.
2.      Schedule the second procedure for 14 days later using the reserved syringe.

Important Notes:
•       Storage of Mixture: Ensure the reserved syringe is stored in a sterile and temperature-controlled environment (as specified by product guidelines).
•       Contraindications: Avoid use in patients with known hypersensitivity to any components, active infections, or bleeding disorders.
•       Adverse Reactions: Monitor for swelling, bruising, or redness. These are usually mild and self-limiting but should be documented.

By adhering to this protocol, you can safely and effectively administer the combined tranexamic acid and I-Reu mixture for under-eye rejuvenation.

Whitening set for dark circles
iReju
1x Traminex’

1 mixing tube
1 luer lock syringe
1 drawing needle 18g

25g cannula wirh introduction needle x2

All pictures shown are for illustration purposes only.
Actual products may vary due to product enhancement.